Test Description: Risk of Ovarian Malignancy Algorithm (ROMA)

The Risk of Ovarian Malignancy Algorithm (ROMA) is a blood test used to assess the risk of ovarian cancer in women with adnexal masses or symptoms suggestive of ovarian cancer. It combines the levels of two tumor markers—CA125 and HE4—along with a patient’s menopausal status to calculate a score that estimates the likelihood of ovarian malignancy. The ROMA score helps distinguish between benign and malignant ovarian conditions, aiding in clinical decision-making, including the need for further diagnostic testing, surgery, or referral to a specialist. This test is particularly useful in guiding the management of women with pelvic masses and evaluating their need for more invasive procedures, such as biopsy or surgery.