The ANA Blot Profile and ENA (Extractable Nuclear Antigen) Profile Qualitative test are used to detect specific autoantibodies in the blood that are associated with autoimmune diseases. The ANA Blot test identifies antinuclear antibodies, which are often present in conditions like lupus, rheumatoid arthritis, and other autoimmune disorders. The ENA Profile further analyzes antibodies against specific nuclear antigens, helping diagnose conditions like systemic lupus erythematosus (SLE), scleroderma, or Sjögren’s syndrome. These tests are essential for diagnosing autoimmune diseases and guiding treatment plans. A blood sample is required for both tests.