Factor V Leiden Mutation is a genetic test that detects a mutation in the Factor V gene (G1691A), which is a common inherited cause of increased blood clotting. This mutation makes Factor V resistant to inactivation by activated protein C, leading to an increased risk of abnormal blood clots, such as deep vein thrombosis (DVT) and pulmonary embolism (PE). The test is typically performed in individuals with a personal or family history of unexplained clotting events or in patients with a history of recurrent miscarriages. Identifying the mutation helps guide treatment decisions, such as anticoagulant therapy, to manage the risk of thrombosis.